Anti-tumor quinazoline compounds

ABSTRACT

4-Ethyl-6-methoxy-7-(oxiranylmethoxy)quinazoline and its isomer 4-ethyl-7-methoxy-6-(oxiranylmethoxy)quinazoline have potent anti-tumor activity in animals.

REFERENCE TO RELATED APPLICATION

This application is a continuation-in-part of co-pending application Ser. No. 011,819 filed February 13, 1979 now U.S. Pat. No. 4,314,943. Procedures 35, 36, 37, and 38 of Ser. No. 011,819 are identical with Procedures 1, 2, 3, and 4 hereof.

FIELD OF THE INVENTION

The invention is concerned with heterocyclic carbon compounds of the quinazoline series (Class 544, Subclass 253) having oxirane-containing substituent groups.

DESCRIPTION OF THE PRIOR ART

The following are referred to as representative of cytostatic compounds known in the prior art which bear the oxirane substituent. None of these is believed to be structurally related to the present compounds in such a way as to raise a presumption of obviousness. The Derwent Publications, Ltd., London WClX 8RP England, Farmdoc Accession Numbers relative to the abstracts of the patents cited are used for reference purposes.

Derwent No. 29,765, South African No. 67/3220 published Sept. 29, 1967, 5,5-Dimethyl-1,3-di(oxiranylmethyl)imidazolidine-2,4-dione is useful as an antitumor agent.

Derwent No. 46879 W/28, Japan No. 5 0030 890 23 published Mar. 27, 1975, 5-Fluoro-1-(oxiranylmethyl)-2,4-(1H,3H)pyrimidindione has anti-carcinogenic activity.

Belgian No. 844,136 published Nov. 3, 1976, (Derwent No. 88859 X/48) 5-Fluoro-2-(oxiranylmethoxy)-4-oxopyrimidine is alleged to be a low toxicity anti-tumor agent.

Quinazoline compounds, also structurally unrelated to the present substances, have been reported to possess anti-tumor activity. The following are illustrative.

Belgium No. 773,818 (Derwent No. 25523Y), published Apr. 12, 1972, Quinazolone diurethanes such as 3-methyl-6-(methoxycarbonylamino)-2-[3-(methoxycarbonylamino)phenyl]quinazolin-4(3H)-one are effective against the mouse L1210 leukemia, pages 1, 7, 8, 9, 10, and 21.

U.S. Pat. No. 3,455,920 patented July 15, 1969 (Derwent No. 38866), 6-Nitro-2-phenyl-1,2,3,4-tetrahydroquinazolin-4-one exhibits cytotoxic activity in vivo against the Walker 256 carcinoma in mice.

Numerous entries appear in Chemical Abstracts Formula Index under the molecular formula C₁₁ H₁₀ N₂ O₂ which corresponds to the quinazoline ring substituted by the (2-oxiranyl)methoxy group, but no compound is indexed having the (2-oxiranyl)methoxy group attached to the quinazoline ring. The most closely related compounds of this formula which is reported is 3-[(2-oxiranyl)methyl]-1,4-dihydro-(4H)-quinazolin-4-one, which structure differs in a number of significant respects from the present compounds.

SUMMARY OF THE INVENTION

This invention is concerned with quinazoline compounds having the following structural formula ##STR1## In Formula I at least one of R⁶ and R⁷ is the oxiranylmethyl group and the other is methyl or a second oxiranylmethyl group. R² and R⁴ are independently selected from hydrogen, alkyl having 1 to 5 carbon atoms, phenyl, substituted phenyl, phenylalkyl having up to 8 carbon atoms, substituted phenylalkyl having up to 8 carbon atoms apart from the substituents. The substituents of the substituted phenyl and substituted phenylalkyl groups are ring attached and there may be one or two of them. They are selected from halogen including chlorine, bromine, iodine, and fluorine, methyl, or methoxy groups.

The compounds of Formula I which are described in Procedures 3 and 4 hereof, namely, those wherein R² is hydrogen, R⁴ is ethyl, and one of R⁶ and R⁷ is oxiranylmethyl and the other is methyl, have utility as intermediates in the preparation of antihypertensive agents as described in our prior co-pending application Ser. No. 011,819. These compounds also have antithrombogenic, hypotensive, ileal relaxant, and smooth muscle relaxant activity, the latter similar to that exhibited by bronchodilator agents. The compound of Procedure 4 inhibits the passive cutaneous anaphylaxis reaction in the rat suggestive of anti-allergy activity.

The quinazoline compounds of this invention have antitumor activity against transplanted animal tumors of established utility for the screening of anticancer agents. The tumors against which the present substances are active include the ascitic tumors P388 and L1210 leukemia which are widely used for primary screening and the B16 melanoma and Lewis Lung carcinoma which are used in secondary screening. A review of the screening strategy with an enumeration of the transplanted animal tumors employed has been published by William T. Bradner in Cancer and Chemotherapy, Vol. 1, pages 221-227 (1980).

Generally, the screening method involves administering a standardized tumor innoculum by intraperitoneal injection to the test animals arranged into groups to which various doses of test compound are administered by intraperitoneal injection, and median survival times in days for the various groups are determined. The results are then expressed as the percent T/C which is the ratio of the median survival time (MST) for the group of treated animals to the MST of the untreated control animals multiplied by 100. Any compound exhibiting a percent T/C≧125 is considered to have significant antitumor activity. Various dosage schedules may be employed such as a single dose on day 1 (d.1), three doses individually on days 1, 5, and 9 after innoculation (d.1, 5, and 9), daily dosage over a period of time such as for nine days (qd.1→9), or others as may be suitable. The following results were obtained with the compounds of Procedures 3 and 4 hereof which were administered suspended in DMSO/saline or aqueous hydroxypropylcellulose.

    ______________________________________                                         Compound of Procedure 3                                                        P388 Leukemia                                                                                           Effect                                                                               Average                                         Treatment                                                                              Dose, IP  MST    MST   Weight  Survivors                               Schedule                                                                               mg/kg/inj Days   % T/C Change, g                                                                              Day 6                                   ______________________________________                                         d.1     150       TOX    TOX   TOX     0/6                                             100       14.5   145   -1.1    6/6                                             50        13.0   130   +0.3    6/6                                             25        11.5   115   +1.2    6/6                                     d.1, 5&9                                                                               100       17.0   170   -2.3    6/6                                             50        13.5   135   -0.4    5/6                                             25        12.0   120   +0.6    6/6                                             12.5      10.0   100   +1.3    6/6                                     qd 1→9                                                                          25        15.0   150   -0.7    6/6                                             12.5      13.0   130   +0.5    6/6                                             6.25      11.0   110   +0.9    6/6                                             3.13       9.5    95   +2.1    6/6                                             Saline    10.0   --    +2.6    10/10                                   ______________________________________                                          Tumor inoculum: 10.sup.6 ascites cells implanted i.p.                          Host: CDF.sub.1 ♀ mice.                                                 TOX: <4/6 mice alive on Day 6                                            

    ______________________________________                                         Compound of Procedure 4                                                        P388 Leukemia                                                                                           Effect                                                                               Average                                         Treatment                                                                              Dose, IP  MST    MST   Weight  Survivors                               Schedule                                                                               mg/kg     Days   % T/C Change, g                                                                              Day 5(30)                               ______________________________________                                         d.1     100       TOX    TOX   -3.7    2/4                                             50        12.5   139   -3.0    4/4                                             25        12.0   133   -2.3    4/4                                             12.5      11.0   122   -1.1    4/4                                     ______________________________________                                          Tumor inoculum: 10.sup.6 ascites cells implanted ip.                           Host: CDF.sub.1 ♀ mice.                                                 TOX: <4/6 or 3/4 mice alive on Day 5.                                    

    ______________________________________                                         Compound of Procedure 3                                                        L1210 Leukemia                                                                                          Effect                                                                               Average                                         Treatment                                                                              Dose, IP  MST    MST   Weight  Survivors                               Schedule                                                                               mg/kg/day Days   % T/C Change, g                                                                              Day 5                                   ______________________________________                                         d.1     120       11.0   183   -3.7    6/6                                             80        10.5   175   -2.3    6/6                                             40        9.0    150   -0.9    5/6                                             20        8.0    133   -1.0    5/6                                     d.1, 5&9                                                                               120       9.5    158   -3.4    4/6                                             80        9.0    150   -1.0    5/5                                             40        7.0    117   +0.2    5/6                                             20        8.0    133   +0.2    5/6                                     qd 1→9                                                                          60        9.0    150   -3.2    6/6                                             40        10.0   167   -2.8    6/6                                             20        9.5    158   -1.1    6/6                                             10        8.5    142   -0.8    6/6                                             Saline    6.0    --    +1.4    10/10                                   ______________________________________                                          Tumor inoculum: 10.sup.6 ascites cells implanted i.p.                          Host: CDF.sub.1 ♀ mice.                                           

    ______________________________________                                         Compound of Procedure 3                                                        B16 Melanoma                                                                                            Effect                                                                               Average                                         Treatment                                                                              Dose, IP  MST    MST   Weight  Survivors                               Schedule                                                                               mg/kg/inj Days   % T/C Change, g                                                                              Day 10(60)                              ______________________________________                                         d.1, 5&9                                                                               120       TOX    TOX   -3.5     5/10                                           80        41.0   178   -1.7     9/10 (2)*                                      40        35.0   152   -0.2    10/10                                           20        29.5   128   -0.3    10/10                                   gd 1→9                                                                          60        30.0   130   -2.4    10/10                                           40        36.5   159   -2.1    10/10 (3)*                                      20        36.0   156   -1.8    10/10                                           10        31.0   135   -1.0    10/10                                           Saline    23.0   --    +2.3    10/10                                   ______________________________________                                          *Tumor-free at autopsy as determined by visual inspection.                     Tumor inoculum: 0.5 ml of a 10% brei, ip                                       Host: BDF.sub.1 ♀ mice.                                                 TOX: <7/10 mice alive on d.10.                                           

    ______________________________________                                         Compound of Procedure 3                                                        Lewis Lung Carcinoma                                                                                           Average                                        Treat-                   Effect Weight                                         ment   Dose, IP  MST     MST    Change,                                                                               Survivors                               Schedule                                                                              mg/kg/inj Days    % T/C  g      Day 10(60)                              ______________________________________                                         d.1, 5&9                                                                              80        >60.0   >400   -0.8   10/10 (6)*                                     60        >60.0   >400   -0.5   10/10 (6)*                                     40        20.0    133    -0.5   10/10 (4)*                              qd 1→9                                                                         60        19.0    127    -2.0    8/10 (3)*                                     40        >60.0   >400   -1.4   10/10 (7)*                                     20        20.0    133    -0.5   10/10 (3)*                                     Saline    15.0    --     -0.4   10/10                                   ______________________________________                                          *Tumor-free.                                                                   Tumor inoculum: 10.sup.6 tumor brei cells, ip                                  Host: BDF.sub.1 ♀ mice.                                                 TOX: <7/10 mice alive on d.10.                                           

DETAILED DESCRIPTION OF THE INVENTION

The compounds of the present invention are prepared by reaction of an intermediate of Formula II wherein R² and R⁴ are as previously defined, one of R^(a) and R^(b) is hydrogen, and the other of R^(a) and R^(b) is hydrogen, or methyl, with epichlorohydrin or epibromohydrin in the presence of a base. ##STR2##

A reaction inert organic liquid reaction medium is employed at a temperature of from about 25° C. up to about 150° C. Suitable bases include sodium and potassium hydroxides, alkoxides, and carbonates. Suitable reaction inert liquid organic media include ethanol, propanol, butanol, dibutyl ether, tetrahydrofuran, benzene, toluene, dimethylsulfoxide, dimethylformamide, dimethylacetamide, ethylene glycol dimethyl ether, ethylene glycol monomethyl ether, hexamethyl phosphoramide, and other alkanols, ethers, and hydrocarbons. A reaction medium in which the reactants are soluble is preferred. Use of a crown ether catalyst such as 18-crown-6 is sometimes advantageous. The preferred system employs finely powdered potassium carbonate as base in dimethylsulfoxide as reaction medium, with epibromohydrin as reactant at a reaction temperature of about 25° C. as described in Procedure 3 below.

The intermediates of Formula II are prepared by methods known in the art, for instance by catalytic debenzylation of the corresponding compound of Formula II wherein one or both of R^(a) and R^(b) is the benzyl group. The latter are produced from the corresponding alkylphenones of Formula III wherein one of R^(c) and R^(d) is benzyl and the other is methyl or benzyl. ##STR3##

Those substances of Formula III wherein R^(c) is benzyl and R^(d) is methyl are prepared from 2-methoxyphenol by conversion thereof to the chloroacetate ester, acylation thereof with an acid of the Formula R⁴ CO₂ H in the presence of polyphosphoric acid, hydrolysis of the chloroacetate ester to yield the corresponding 1-(3-hydroxy-4-methoxyphenyl)phenone, and benzylation of the latter to yield the corresponding substances of Formula III wherein R^(c) is benzyl and R^(d) is methyl. This is illustrated in Procedure 2 below.

Those intermediates of Formula III wherein R^(c) is methyl, and R^(d) is benzyl are prepared by acylation of 2-methoxyphenol with a carboxylic acid of the formula R⁴ CO₂ H in the fashion referred to above followed by benzylation of the corresponding 3-methoxy-4-hydroxyphenone to yield the compound of Formula III wherein R^(c) is methyl, and R^(d) is benzyl.

The intermediates of Formula III are converted to those of Formula II by conventional means for the synthesis of quinolines such as are illustrated in U.S. Pat. No. 3,248,292 patented Apr. 26, 1966. The last step is removal of the benzyl group represented by R^(c) or R^(d) in Formula III to yield the corresponding hydroxyl compound of Formula II.

An alternative method for production of the intermediates of Formula II wherein R^(a) is methyl, and R^(b) is hydrogen or R^(a) and R^(b) are each hydrogen atoms is by hydrolysis of the corresponding compound wherein R^(a) and R^(b) are each methyl with concentrated aqueous hydrobromic acid at the reflux temperature as is illustrated in Procedures 1 and 5 hereof.

DESCRIPTION OF SPECIFIC EMBODIMENTS

In the following procedures, temperatures are expressed in degrees centigrade (°). Melting points are corrected values according to the U.S.P. method where indicated (corr.). Abbreviations employed are MeOH (methanol), DMSO (dimethylsulfoxide), i-PrOH (isopropanol), abs.EtOH (absolute ethanol), EtOAc (ethyl acetate), EtOH (95% ethanol), Et₂ O (diethyl ether), THF (tetrahydrofuran), MEK (2-butanone), i-PrOAc (isopropyl acetate), i-Pr₂ O (di-isopropyl ether), AcOH (acetic acid), TLC (thin layer chromatography), d (decomposition). Other abbreviations have conventional established meanings.

Procedure 1. 4-ETHYL-6-METHOXYQUINAZOLIN-7-OL.--A solution of 100 g. (0.46 mole) of 4-ethyl-6,7-dimethoxyqunazoline (CAS Registry No. 4015-32-1, m.p. 146°-148°) in 250 ml. of 48% hydrobromic acid was refluxed 3.5 hrs. at which time only a trace of this starting material was evident by TLC (9:1 CHCl₃ -MeOH; silica). The mixture was cooled to 25° and neutralized (pH 7) with concentrated NH₄ OH. After the suspension had been chilled overnight (5°), the crude grey-green precipitate was collected on a filter and dried--first overnight in air and then in a vacuum oven at 50°/60 mm for 18 hrs. The dry solid (70 g., m.p. 210°-215°) was recrystallized from MeOH-(i-Pr)₂ O to give 42 g. (43%) of chartreuse powder, m.p. 221°-224° (uncorr.). The identity of the product was confirmed by examination of the IR spectrum.

Procedure 2. 4-ETHYL-7-METHOXYQUINAZOLIN-6-OL.--2-Methoxyphenol was esterified by reaction with chloroacetyl chloride to give in 75% yield, 2-methoxyphenyl chloroacetate, m.p. 60°-61.5°. This material was acylated with propionic acid in the presence of polyphosphoric acid to produce 2-methoxy-5-propionylphenyl chloroacetate in 75% yield, m.p. 77°-79.5° C. This ester was hydrolyzed with sodium acetate in methanol to yield 1-(3-hydroxy-4-methoxyphenyl)-1-propanone, m.p. 91°-92°, yield 90%. Benzylation of the later by treatment in acetone with benzyl chloride and potassium carbonate yielded 1-(3-benzyloxy-4-methoxyphenyl)-1-propanone, m.p. 83°-85°, yield 96%. The latter was then nitrated by treatment with 1:3 nitric acid/acetic acid at 18°-20° to yield 1-(2-nitro-4-methoxy-5-benzyloxyphenyl)-1-propanone, m.p. 120.5°-123°, yield 65%. Reduction of this material with hydrazine hydrate and Raney nickel yielded 1-(2-amino-4-methoxy-5-benzyloxyphenyl)-1-propanone. The latter was cyclized by treatment with formic acid and formamide to yield 6-benzyloxy-4-ethyl-7-methoxyquinoline, yield 80%, m.p. 132°-134°. Catalytic hydrogenation of the latter resulted in debenzylation to yield 4-ethyl-7-methoxyquinolin-6-ol in 85% yield, m.p. 200°-202°.

Procedure 3. 7-(OXIRANYLMETHOXY)-4-ETHYL-6-METHOXYQUINAZOLINE.--A suspension of finely powdered anhyd. K₂ CO₃ in 70 ml. of DMSO containing 6.2 g. (0.03 mole) of 4-ethyl-6-methoxyquinazolin-7-ol was stirred at 25° for 15 min. Epibromohydrin (10.3 g., 0.075 mole) was added in one portion and stirring was continued for 24 hrs. at 25°, after which the mixture was poured into 800 ml. H₂ O and extracted twice with 200 ml. EtOAc and twice with 100 ml. CH₂ Cl₂. The combined organic layers were dried (anhyd. Na₂ CO₃), filtered and evaporated at 100°/60 mm to afford 13.5 g. of crude yellow solid which was recrystallized from EtOAc to give 4.75 g. of the pure intermediate, m.p. 120.0°-121.0° (corr.). Elemental analysis for C, H, and N confirmed the formula C₁₄ H₁₆ N₂ O₃.

Procedure 4. 6-(OXIRANYLMETHOXY)-4-ETHYL-7-METHOXYQUINAZOLINE.--4-Ethyl-7-methoxyquinazolin-6-ol was treated as described in Procedure 3, yield 67%, m.p. 120.0°-122.0° after recrystallization from EtOAc. Elemental analysis for C, H, and N confirmed the formula C₁₄ H₁₆ N₂ O₃.

Procedure 5. 4-ETHYL-6,7-QUINAZOLINEDIOL.--A solution of 4-ethyl-6,7-dimethoxyquinazoline in 150 ml. of 48% HBr was refluxed for 4 hrs. and then cooled to room temperature and neutralized to pH 7 with concentrated ammonium hydroxide. The suspension was chilled overnight and the precipitate then collected on a filter and dried in the air overnight and then in a vacuum oven at 50°/60 mm for 18 hrs. The diol was then separated by fractional crystallization of 19 g. of the crude solid using first MeOH-Abs.EtOH (4:1) and then two recrystallizations from MeOH-dioxane (4:1) and a fourth crystallization from MeOH-H₂ O by allowing the methanol to evaporate from the boiling solution until crystallization commenced. The diol was a yellow crystalline solid, yield 4.2 g., m.p. 277.0°-278.0° (dec., corr.). Elemental analysis for carbon, hydrogen, and nitrogen corresponded to the formula C₁₀ H₁₀ N₂ O₂.

Procedure 6. 6,7-DI(OXIRANYLMETHOXY)-4-ETHYLQUINAZOLINE.--4-Ethyl-6,7-quinazolinediol when treated with epibromohydrin in the presence of potassium carbonate in DMSO as reaction medium according to the method of Procedure 3, the desired product is obtained.

The 6,7-dimethoxyquinazolines listed in the following table have been prepared by the method described in U.S. Pat. No. 3,248,292. They are suitable for conversion according to the methods of Procedures 1 and 3 to the products of Formula I wherein R² and R⁴ have the meanings given in the table, R⁶ is methyl and R⁷ is oxiranylmethyl. The corrected melting points and recrystallization solvents for the quinazoline starting materials are stated.

    __________________________________________________________________________     6,7-Dimethoxyquinazolines                                                       ##STR4##                                                                      No.                                                                               R.sup.2 R.sup.4       m.p.  Solvent Molecular Formula                       __________________________________________________________________________     1  H       CH.sub.2 CH.sub.2 CH.sub.3                                                                   108.5-110.5                                                                          acetonitrile                                                                           C.sub.13 H.sub.16 N.sub.2 O.sub.2       2  CH.sub.3                                                                               CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                                         90.5-91.5                                                                            heptane C.sub.16 H.sub.22 N.sub.2 O.sub.2       3  CH.sub.3                                                                               CH.sub.2 CH.sub.2 CH.sub.3                                                                     111-112.5                                                                          isopropyl                                                                              C.sub.14 H.sub.18 N.sub.2 O.sub.2       4  H       CH(CH.sub.3).sub.2                                                                           93-95 isopropyl                                                                              C.sub.13 H.sub.16 N.sub.2 O.sub.2       5  H       H             146-148                                                                              ethyl acetate                                                                          C.sub.10 H.sub.10 N.sub.2 O.sub.2                                      butanone                                        6  H       CH.sub.2 CH.sub.2 CH(CH.sub.3).sub.2                                                         79.5-81.5                                                                            isopropyl ether                                                                        C.sub.15 H.sub.20 N.sub.2 O.sub.2       7  CH.sub.2 CH.sub.2 CH.sub.3                                                             CH.sub.2 CH.sub.2 CH.sub.3                                                                   157.5-159.5                                                                          ethyl acetate                                                                          C.sub.16 H.sub.22 N.sub.2 O.sub.2.H                                            Cl                                      8  CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                            117-119                                                                              acetonitrile                                                                           C.sub.13 H.sub.16 N.sub.2 O.sub.2                                      isopropyl ether                                 9  H                                                                                       ##STR5##       145-146.5                                                                          acetonitrile butanone                                                                  C.sub.17 H.sub.14 Cl.sub.2 N.sub.2                                             O.sub.2                                 10 CH.sub.3                                                                               CH(CH.sub.3).sub.2                                                                           96.5-98                                                                              isopropyl ether                                                                        C.sub.14 H.sub.18 N.sub.2 O.sub.2       11 H       CH.sub.3      150-152                                                                              acetonitrile                                                                           C.sub.11 H.sub.12 N.sub.2 O.sub.2                                      ethyl acetate                                   12 CH.sub.3                                                                               CH.sub.3      112-114                                                                              acetonitrile                                                                           C.sub.12 H.sub.14 N.sub.2 O.sub.2       13 H       CH.sub.2 CH.sub.3                                                                            146-148                                                                              acetonitrile                                                                           C.sub.12 H.sub.14 N.sub.2 O.sub.2       14 H                                                                                       ##STR6##     173-175                                                                              acetonitrile                                                                           C.sub.16 H.sub.14 N.sub.2 O.sub.2       15 CH.sub.3                                                                                ##STR7##     170-172                                                                              ethyl acetate                                                                          C.sub. 17 H.sub.16 N.sub.2                                                     O.sub.2                                 16 H                                                                                       ##STR8##     130-132                                                                              acetonitrile                                                                           C.sub.17 H.sub.16 N.sub.2 O.sub.2       17 H                                                                                       ##STR9##     145-147                                                                              acetonitrile                                                                           C.sub.18 H.sub.18 N.sub.2 O.sub.2       18 H                                                                                       ##STR10##    155-157                                                                              acetonitrile ethanol                                                                   C.sub.17 H.sub.15 ClN.sub.2                                                    O.sub.2                                 19 H                                                                                       ##STR11##    134-136                                                                              acetonitrile                                                                           C.sub.18 H.sub.17 ClN.sub.2                                                    O.sub.2                                 20 CH.sub.3                                                                                ##STR12##    166-168                                                                              acetonitrile butanone                                                                  C.sub.19 H.sub.19 ClN.sub.2                                                    O.sub.2                                 21 H                                                                                       ##STR13##    146-148                                                                              acetonitrile                                                                           C.sub.20 H.sub.22 N.sub.2 O.sub.4       22 CH.sub.3                                                                               H             163-165                                                                              acenotrile                                                                             C.sub.11 H.sub.12 N.sub.2 O.sub.2       __________________________________________________________________________ 

What is claimed is:
 1. A compound having Formula I ##STR14## wherein one of R⁶ and R⁷ is oxiranylmethyl, and the other is methyl or oxiranylmethyl, and R² and R⁴ are independently selected from the group consisting of hydrogen, alkyl having from 1 to 5 carbon atoms, phenyl, substituted phenyl, phenylalkyl having up to 8 carbon atoms, substituted phenylalkyl having up to 8 carbon atoms apart from the substituents, wherein said substituted phenyl and substituted phenylalkyl have one or two ring attached groups independently selected from halogen, methyl, or methoxy groups.
 2. The compound of claim 1, 4-ethyl-6-methoxy-7-(oxiranylmethoxy)quinazoline.
 3. The compound of claim 1, 4-ethyl-7-methoxy-6-(oxiranylmethoxy)quinazoline. 